SILENCE THERAPEUTICS PLC
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Next accounts due
2026-06-30 (in 1mo)
Last filed for 2024-12-31
Confirmation statement due
2026-08-19 (in 3mo)
Last made up 2025-08-05
Watchouts
Cash
£97M
+79.1% vs 2023
Net assets
£107M
+526.9% vs 2023
Employees
116
+0.9% vs 2023
Profit before tax
-£45M
+10.4% vs 2023
Watchouts
Facts from the Companies House register and the latest accounts — not a rating
-
3 officer resignations in last 12 months
Multiple officers have left the board recently — see the People section for who.
Name history
Renamed 2 times since incorporation
- SILENCE THERAPEUTICS PLC 2007-04-26 → present
- SR PHARMA PLC 1999-06-21 → 2007-04-26
- STANFORD ROOK HOLDINGS PLC 1994-11-18 → 1999-06-21
Net assets
2-year trend · vs Health Care median
Accounts
2-year trend · latest reflected 2024-12-31
| Metric | Trend | 2023-12-31 | 2024-12-31 |
|---|---|---|---|
| Turnover | £25,375,000 | £33,833,000 | |
| Operating profit | -£49,504,000 | -£49,033,000 | |
| Profit before tax | -£50,310,000 | -£45,080,000 | |
| Net profit | -£43,267,000 | -£35,242,000 | |
| Cash | £54,031,000 | £96,786,000 | |
| Total assets less current liabilities | £76,218,000 | £148,196,000 | |
| Net assets | £17,050,000 | £106,883,000 | |
| Equity | £17,050,000 | £106,883,000 | |
| Average employees | 115 | 116 | |
| Wages | £15,383,000 | £15,209,000 |
Values shown as filed in the company's annual accounts. — indicates the figure wasn't present under that line item in that period. About these numbers
Ratios
Computed from the line items above — sparklines read oldest → newest
| Ratio | Trend | 2023-12-31 | 2024-12-31 |
|---|---|---|---|
| Operating margin | -195.1% | -144.9% | |
| Net margin | -170.5% | -104.2% | |
| Return on capital employed | -65.0% | -33.1% | |
| Gearing (liabilities / total assets) | 81.9% | 33.9% | |
| Current ratio | 4.56x | 11.11x | |
| Interest cover | -1456.00x | -662.61x |
Margins divide P&L lines by turnover. Gearing is liabilities over total assets. Current ratio is current assets over creditors falling due within one year. Interest cover is operating profit over absolute finance costs. Sector-distribution context coming next.
Audit & accounting basis
- Accounting basis
- IFRS
- Reporting scope
- Consolidated group
- Auditor
- PricewaterhouseCoopers LLP
- Audit opinion
- Unqualified (clean)
- Going concern
- Affirmed
“Our evaluation of the directors' assessment of the group's and the parent company's ability to continue to adopt the going concern basis of accounting included: Testing the mathematical accuracy of the cash flow forecasts; Challenging management's forecasts for reasonableness, including understanding the planned cash outflows / inflows; Assessing management's ability to forecast accurately by comparing the current year actual results to previous cashflow forecasts; Performing sensitivity analysis on management's model to consider the potential impact of certain downside but plausible scenarios; and Evaluating the disclosures within the financial statements.”
Group structure
- SILENCE THERAPEUTICS PLC · parent
- Silence Therapeutics GmbH 100%
- Silence Therapeutics (London) Ltd 100%
- Innopeg Ltd 100%
- Silence Therapeutics Inc. 100%
Significant events
- “In December 2024, we presented positive interim results from the Phase 1 portion of the SANRECO Phase 1/2 clinical trial of divesiran in PV patients at the 66th American Society of Hematology (ASH) Annual Meeting.”
- “In December 2024, we also announced that the first subject has been dosed in the Phase 2 portion of the SANRECO clinical trial.”
Auditor, going-concern and subsidiary information is drawn from the narrative of the latest annual accounts. About these numbers
People
6 active · 61 resigned
| Name | Role | Appointed | Born | Nationality |
|---|---|---|---|---|
| HELLUMS, Rhonda | Secretary | 2024-01-26 | — | — |
| EDE-GOLIGHTLY, James Lawrence | Director | 2025-12-14 | Aug 1979 | British |
| HELLUMS, Rhonda | Director | 2025-12-18 | Dec 1971 | American |
| LEMUS, Dave | Director | 2018-06-21 | Oct 1962 | American |
| MCINERNEY, Tim | Director | 2025-05-05 | Oct 1960 | American |
| ROSS, Iain Gladstone | Director | 2019-04-25 | Jan 1954 | British |
Show 61 resigned officers
| Name | Role | Appointed | Resigned |
|---|---|---|---|
| DAVIES, Jon Melvyn | Secretary | 1994-11-18 | 2010-02-27 |
| ELLAM, David John | Secretary | 2016-07-18 | 2019-01-09 |
| FREEBORN, Tim | Secretary | 2012-08-02 | 2016-07-19 |
| HERRMANN, Max Stephen | Secretary | 2010-05-14 | 2012-08-02 |
| MURPHY, Sarah | Secretary | 2022-09-28 | 2023-12-22 |
| QUINN, Robert, Dr | Secretary | 2019-01-09 | 2020-12-01 |
| RUSKIN, Barbara, Dr. | Secretary | 2020-12-01 | 2022-09-28 |
| TEMPLE SECRETARIES LIMITED | Corporate Nominee Secretary | 1994-11-18 | 1994-11-18 |
| BOYLE, Eric James | Director | 1994-11-18 | 2004-05-20 |
| CAMPION, Giles Victor, Dr | Director | 2020-06-09 | 2023-07-01 |
| CAMPION, Giles Victor, Dr | Director | 2020-05-19 | 2020-06-09 |
| CARSWELL, John Wilson | Director | 1994-11-18 | 1995-03-01 |
| CHARD, Timothy | Director | 1997-02-21 | 2003-07-20 |
| CHENG, Annie | Director | 2013-05-30 | 2014-09-02 |
| CHRISTELY, Thomas | Director | 2011-09-19 | 2012-02-09 |
| CLANCY, Annette | Director | 2008-07-01 | 2012-08-02 |
| COLLINSON, Stuart John Myles, Dr | Director | 2016-01-18 | 2016-04-05 |
| CURNOCK COOK, Jeremy Lawrence | Director | 2005-07-11 | 2010-01-05 |
| DAVIDSON, Michael, Dr. | Director | 2021-01-06 | 2025-08-11 |
| DAVIES, Jon Melvyn | Director | 1994-11-18 | 2010-02-27 |
| EDE-GOLIGHTLY, James Lawrence | Director | 2019-04-25 | 2025-06-26 |
| ELLAM, David John | Director | 2016-07-18 | 2019-01-09 |
| FREEBORN, Timothy Charles Adrian | Director | 2012-10-08 | 2016-06-17 |
| GEDDES, Duncan, Prof | Director | 2000-08-21 | 2002-05-22 |
| GRAY, Alistair William | Director | 2015-11-12 | 2024-04-30 |
| HAWORTH, Philip | Director | 2010-01-05 | 2011-08-01 |
| HERRMANN, Max Stephen | Director | 2010-05-14 | 2012-08-02 |
| HILL, David | Director | 2003-05-19 | 2004-06-18 |
| JENKINS, Annalisa | Director | 2017-10-16 | 2018-08-20 |
| KARLSSON, Lars Georg Emanuel | Director | 2015-01-08 | 2016-04-05 |
| KENNARD, David Anthony, Dr | Director | 1997-05-12 | 2003-07-17 |
| KHAN, Michael Mohamed Tarik, Dr | Director | 2012-09-18 | 2016-06-17 |
| LAMBERT, John Anthony | Director | 2000-09-18 | 2004-05-20 |
| LANG, Thomas, Dr | Director | 1998-02-10 | 2002-05-21 |
| MACK, David | Director | 2010-01-05 | 2013-06-26 |
| MORTAZAVI, Ali | Director | 2012-08-02 | 2018-06-04 |
| PARKER, Stephen Barry, Dr | Director | 2013-11-18 | 2019-04-25 |
| PATTISON, John, Professor | Director | 1994-11-18 | 1999-08-31 |
| RANDALL, Jeremy Anthony Philip | Director | 2008-07-01 | 2013-11-18 |
| REYNOLDS, Hugh Ronald Peter | Director | 2004-05-20 | 2010-01-05 |
| RICHARDS, Andrew John Mcglashan, Dr | Director | 2016-09-14 | 2019-04-16 |
| RIDDELL, Alastair James, Dr | Director | 2013-11-18 | 2015-09-22 |
| ROMANO, Steven, Dr | Director | 2019-07-29 | 2023-04-01 |
| ROOK, Graham Arthur William, Professor | Director | 1994-11-18 | 2001-09-27 |
| ROSS, Iain Gladstone | Director | 2004-05-28 | 2010-02-27 |
| ROSS, Iain Gladstone | Director | 2003-01-07 | 2003-03-04 |
| ROTHERA, Mark | Director | 2020-09-14 | 2022-02-22 |
| RUGHEIMER, Iain Nils Hessey | Director | 1994-12-19 | 2008-07-01 |
| SEDGWICK, Anthony, Dr | Director | 2012-02-09 | 2012-08-02 |
| SOLOMON, David Horn, Dr | Director | 2018-07-17 | 2019-12-17 |
| STANFORD, Cynthia Ann | Director | 1994-11-18 | 1998-03-25 |
| STANFORD, John Lawson, Dr | Director | 1994-11-18 | 2001-09-27 |
| STURGE, Simon John | Director | 2013-08-21 | 2016-01-18 |
| TOOMAN, Craig | Director | 2022-02-22 | 2025-12-14 |
| TOPPER, James | Director | 2010-01-05 | 2011-07-29 |
| U'PRICHARD, David Charles, Dr | Director | 2005-07-11 | 2011-12-31 |
| VICK, Jeffery Scott | Director | 2007-07-27 | 2008-07-17 |
| WARREN, Simon Oliver Henry | Director | 1994-11-18 | 1998-03-25 |
| WETZEL, Bernd Otto, Dr | Director | 2005-07-11 | 2010-01-05 |
| COMPANY DIRECTORS LIMITED | Corporate Nominee Director | 1994-11-18 | 1994-11-18 |
| TEMPLE SECRETARIES LIMITED | Corporate Nominee Director | 1994-11-18 | 1994-11-18 |
Ownership
Persons with significant control
| Name | Kind | Nature of control | Notified | Status |
|---|---|---|---|---|
| Mr Richard Ian Griffiths | Individual | Shares 25–50% | 2025-08-04 | Active |
| Mr Richard Ian Griffiths | Individual | ownership-of-shares-25-to-50-percent-as-firm | 2017-07-27 | Ceased 2021-11-30 |
Filing timeline
Last 20 of 364 total filings
Material constitutional events — rename, articles re-file, resolution
- 2025-08-04 RESOLUTIONS Resolution
- 2025-08-04 MA Memorandum articles
| Date | Type | Category | Description | |
|---|---|---|---|---|
| 2026-01-09 | AP01 | officers | Appoint person director company with name date | |
| 2026-01-08 | AP01 | officers | Appoint person director company with name date | |
| 2026-01-06 | TM01 | officers | Termination director company with name termination date | |
| 2025-08-20 | SH01 | capital | Capital allotment shares | |
| 2025-08-20 | PSC01 | persons-with-significant-control | Notification of a person with significant control | |
| 2025-08-20 | PSC09 | persons-with-significant-control | Withdrawal of a person with significant control statement | |
| 2025-08-19 | CS01 | confirmation-statement | Confirmation statement with updates | |
| 2025-08-18 | TM01 | officers | Termination director company with name termination date | |
| 2025-08-04 | RESOLUTIONS | resolution | Resolution | |
| 2025-08-04 | MA | incorporation | Memorandum articles | |
| 2025-06-27 | TM01 | officers | Termination director company with name termination date | |
| 2025-05-27 | AA | accounts | Accounts with accounts type group | |
| 2025-05-13 | AP01 | officers | Appoint person director company with name date | |
| 2025-05-12 | SH01 | capital | Capital allotment shares | |
| 2024-12-11 | SH01 | capital | Capital allotment shares | |
| 2024-08-28 | CS01 | confirmation-statement | Confirmation statement with updates | |
| 2024-08-19 | SH01 | capital | Capital allotment shares | |
| 2024-08-16 | SH01 | capital | Capital allotment shares | |
| 2024-08-16 | SH01 | capital | Capital allotment shares | |
| 2024-08-16 | SH01 | capital | Capital allotment shares |
Public-record activity
Raw counts from Companies House — last 12–24 months
- Filings
- 14
- Capital events
- 7
- Officers appointed
- 3
- Officers resigned
- 3
last 12 months
last 24 months
last 12 months
last 12 months
Direct counts from the register. No score, no rating — see the Filing timeline for the underlying events.
Year-on-year
FY2023 → FY2024 · period ending 2024-12-31 vs 2023-12-31
-
Turnover
+33.3%
£25,375,000 £33,833,000
-
Cash
+79.1%
£54,031,000 £96,786,000
-
Net assets
+526.9%
£17,050,000 £106,883,000
-
Employees
+0.9%
115 116
-
Operating profit
+1%
-£49,504,000 -£49,033,000
-
Profit before tax
+10.4%
-£50,310,000 -£45,080,000
-
Wages
-1.1%
£15,383,000 £15,209,000
Each % is (latest − prior) ÷ |prior| for the line item as filed. The comparison is only shown when the latest and prior accounts cover broadly equal-length periods — short or long stubs (typical around incorporation or a year-end change) are suppressed rather than misrepresented. Lines a company doesn't report are omitted. About these numbers